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Burn and smoke injury activates poly(ADP-ribose)polymerase in circulating leukocytes
The nuclear enzyme poly(ADP-ribose)polymerase (PARP) plays a significant role in the pathogenesis of various forms of critical illness. DNA strand breaks induced by oxidative and nitrative stress trigger the activation of PARP, and PARP, in turn, mediates cell death and promotes pro-inflammatory res...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2011
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3128177/ https://ncbi.nlm.nih.gov/pubmed/21330947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0b013e318212988c |
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