Dynamic Chromatin Localization of Sirt6 Shapes Stress- and Aging-Related Transcriptional Networks

The sirtuin Sirt6 is a NAD-dependent histone deacetylase that is implicated in gene regulation and lifespan control. Sirt6 can interact with the stress-responsive transcription factor NF-κB and regulate some NF-κB target genes, but the full scope of Sirt6 target genes as well as dynamics of Sirt6 oc...

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Detalhes bibliográficos
Main Authors: Kawahara, Tiara L. A., Rapicavoli, Nicole A., Wu, Angela R., Qu, Kun, Quake, Stephen R., Chang, Howard Y.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128103/
https://ncbi.nlm.nih.gov/pubmed/21738489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1002153
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