The deacylase SIRT5 supports melanoma viability by influencing chromatin dynamics

Cutaneous melanoma remains the most lethal skin cancer, and ranks third among all malignancies in terms of years of life lost. Despite the advent of immune checkpoint and targeted therapies, only roughly half of patients with advanced melanoma achieve a durable remission. Sirtuin 5 (SIRT5) is a memb...

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Bibliografische gegevens
Gepubliceerd in:J Clin Invest
Hoofdauteurs: Giblin, William, Bringman-Rodenbarger, Lauren, Guo, Angela H., Kumar, Surinder, Monovich, Alexander C., Mostafa, Ahmed M., Skinner, Mary E., Azar, Michelle, Mady, Ahmed S.A., Chung, Carolina H., Kadambi, Namrata, Melong, Keith-Allen, Lee, Ho-Joon, Zhang, Li, Sajjakulnukit, Peter, Trefely, Sophie, Varner, Erika L., Iyer, Sowmya, Wang, Min, Wilmott, James S., Soyer, H. Peter, Sturm, Richard A., Pritchard, Antonia L., Andea, Aleodor A., Scolyer, Richard A., Stark, Mitchell S., Scott, David A., Fullen, Douglas R., Bosenberg, Marcus W., Chandrasekaran, Sriram, Nikolovska-Coleska, Zaneta, Verhaegen, Monique E., Snyder, Nathaniel W., Rivera, Miguel N., Osterman, Andrei L., Lyssiotis, Costas A., Lombard, David B.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2021
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC8203465/
https://ncbi.nlm.nih.gov/pubmed/33945506
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI138926
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