Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse

Adaptive evolution is characterized by positive and parallel, or repeated selection of mutations. Mouse adaptation of influenza A virus (IAV) produces virulent mutants that demonstrate positive and parallel evolution of mutations in the hemagglutinin (HA) receptor and non-structural protein 1 (NS1)...

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Hauptverfasser: Ping, Jihui, Keleta, Liya, Forbes, Nicole E., Dankar, Samar, Stecho, William, Tyler, Shaun, Zhou, Yan, Babiuk, Lorne, Weingartl, Hana, Halpin, Rebecca A., Boyne, Alex, Bera, Jayati, Hostetler, Jessicah, Fedorova, Nadia B., Proudfoot, Katie, Katzel, Dan A., Stockwell, Tim B., Ghedin, Elodie, Spiro, David J., Brown, Earl G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2011
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128085/
https://ncbi.nlm.nih.gov/pubmed/21738783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021740
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