Genomic and Protein Structural Maps of Adaptive Evolution of Human Influenza A Virus to Increased Virulence in the Mouse

Adaptive evolution is characterized by positive and parallel, or repeated selection of mutations. Mouse adaptation of influenza A virus (IAV) produces virulent mutants that demonstrate positive and parallel evolution of mutations in the hemagglutinin (HA) receptor and non-structural protein 1 (NS1)...

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Main Authors: Ping, Jihui, Keleta, Liya, Forbes, Nicole E., Dankar, Samar, Stecho, William, Tyler, Shaun, Zhou, Yan, Babiuk, Lorne, Weingartl, Hana, Halpin, Rebecca A., Boyne, Alex, Bera, Jayati, Hostetler, Jessicah, Fedorova, Nadia B., Proudfoot, Katie, Katzel, Dan A., Stockwell, Tim B., Ghedin, Elodie, Spiro, David J., Brown, Earl G.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3128085/
https://ncbi.nlm.nih.gov/pubmed/21738783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0021740
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