Isoform-specific regulation of Akt by PDGF-induced reactive oxygen species

Isoform-specific signaling of Akt, a major signaling hub and a prominent therapeutic target, remained poorly defined until recently. Subcellular distribution, tissue-specific expression, substrate specificity, and posttranslational modifications are believed to underlie isoform-specific signaling of...

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Autores principales: Wani, Revati, Qian, Jiang, Yin, Leimiao, Bechtold, Erika, King, S. Bruce, Poole, Leslie B., Paek, Eunok, Tsang, Allen W., Furdui, Cristina M.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2011
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127936/
https://ncbi.nlm.nih.gov/pubmed/21670275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1011665108
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