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Two classes of BRC repeats in BRCA2 promote RAD51 nucleoprotein filament function by distinct mechanisms
The human tumor suppressor protein BRCA2 plays a key role in recombinational DNA repair. BRCA2 recruits RAD51 to sites of DNA damage through interaction with eight conserved motifs of approximately 35 amino acids, the BRC repeats; however, the specific function of each repeat remains unclear. Here,...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2011
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3127913/ https://ncbi.nlm.nih.gov/pubmed/21670257 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1106971108 |
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