Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2
The glucocorticoid receptor (GR) and the tumor supressor p53 mediate different stress responses. We have studied the mechanism of their mutual inhibition in normal endothelial cells (HUVEC) in response to hypoxia, a physiological stress, and mitomycin C, which damages DNA. Dexamethasone (Dex) stimul...
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| Udgivet i: | Genes Dev |
|---|---|
| Principais autores: | , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Cold Spring Harbor Laboratory Press
2001
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312780/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11562347/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.202201 |
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