Defect in the p53-Mdm2 Autoregulatory Loop Resulting from Inactivation of TAF(II)250 in Cell Cycle Mutant tsBN462 Cells

The cell cycle arrest and proapoptotic functions of p53 are under tight control by Mdm2. After stress activation of p53 by nontranscriptional mechanisms, transcription of the mdm2 gene results in increased synthesis of Mdm2 and down-regulation of p53. Disruption of this autoregulatory loop has profo...

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Detalhes bibliográficos

Publicado no:	Mol Cell Biol
Principais autores:	Wasylyk, Christine, Wasylyk, Bohdan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis 2000
Assuntos:	Cell Growth and Development
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86011/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10891494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.15.5554-5570.2000
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