Defect in the p53-Mdm2 Autoregulatory Loop Resulting from Inactivation of TAF(II)250 in Cell Cycle Mutant tsBN462 Cells

The cell cycle arrest and proapoptotic functions of p53 are under tight control by Mdm2. After stress activation of p53 by nontranscriptional mechanisms, transcription of the mdm2 gene results in increased synthesis of Mdm2 and down-regulation of p53. Disruption of this autoregulatory loop has profo...

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Библиографические подробности

Опубликовано в::	Mol Cell Biol
Главные авторы:	Wasylyk, Christine, Wasylyk, Bohdan
Формат:	Artigo
Язык:	Inglês
Опубликовано:	Taylor & Francis 2000
Предметы:	Cell Growth and Development
Online-ссылка:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86011/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10891494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.15.5554-5570.2000
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