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Defect in the p53-Mdm2 Autoregulatory Loop Resulting from Inactivation of TAF(II)250 in Cell Cycle Mutant tsBN462 Cells
The cell cycle arrest and proapoptotic functions of p53 are under tight control by Mdm2. After stress activation of p53 by nontranscriptional mechanisms, transcription of the mdm2 gene results in increased synthesis of Mdm2 and down-regulation of p53. Disruption of this autoregulatory loop has profo...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Microbiology
2000
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC86011/ https://ncbi.nlm.nih.gov/pubmed/10891494 |
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