Defect in the p53-Mdm2 Autoregulatory Loop Resulting from Inactivation of TAF(II)250 in Cell Cycle Mutant tsBN462 Cells

The cell cycle arrest and proapoptotic functions of p53 are under tight control by Mdm2. After stress activation of p53 by nontranscriptional mechanisms, transcription of the mdm2 gene results in increased synthesis of Mdm2 and down-regulation of p53. Disruption of this autoregulatory loop has profo...

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Pubblicato in:	Mol Cell Biol
Autori principali:	Wasylyk, Christine, Wasylyk, Bohdan
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis 2000
Soggetti:	Cell Growth and Development
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC86011/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10891494/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/mcb.20.15.5554-5570.2000
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