Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2

The glucocorticoid receptor (GR) and the tumor supressor p53 mediate different stress responses. We have studied the mechanism of their mutual inhibition in normal endothelial cells (HUVEC) in response to hypoxia, a physiological stress, and mitomycin C, which damages DNA. Dexamethasone (Dex) stimul...

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Detalles Bibliográficos

Publicado en:	Genes Dev
Principais autores:	Sengupta, Sagar, Wasylyk, Bohdan
Formato:	Artigo
Idioma:	Inglês
Publicado:	Cold Spring Harbor Laboratory Press 2001
Assuntos:	Research Paper
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312780/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11562347/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.202201
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