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Ligand-dependent interaction of the glucocorticoid receptor with p53 enhances their degradation by Hdm2

The glucocorticoid receptor (GR) and the tumor supressor p53 mediate different stress responses. We have studied the mechanism of their mutual inhibition in normal endothelial cells (HUVEC) in response to hypoxia, a physiological stress, and mitomycin C, which damages DNA. Dexamethasone (Dex) stimul...

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Bibliografiske detaljer
Main Authors: Sengupta, Sagar, Wasylyk, Bohdan
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2001
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC312780/
https://ncbi.nlm.nih.gov/pubmed/11562347
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.202201
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