A homeotic mutation in the trithorax SET domain impedes histone binding

Trithorax (TRX) is a Drosophila SET domain protein that is required for the correct expression of homeotic genes. Here, we show that the TRX SET domain efficiently binds to core histones and nucleosomes. The primary target for the SET domain is histone H3 and binding requires the N-terminal histone...

Full description

Bibliographic Details

Published in:	Genes Dev
Main Authors:	Katsani, Katerina R., Arredondo, Juan J., Kal, Arnoud J., Verrijzer, C. Peter
Format:	Artigo
Language:	Inglês
Published:	Cold Spring Harbor Laboratory Press 2001
Subjects:	Research Communication
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC312775/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11544176/ https://ncbi.nlm.nih.govhttps://doi.org/10.1101/gad.201901
Tags:	Add Tag No Tags, Be the first to tag this record!