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Occupation of Either Site for the Neurosteroid Allopregnanolone Potentiates the Opening of the GABA(A) Receptor Induced from Either Transmitter Binding Site
Potentiating neuroactive steroids are potent and efficacious modulators of the GABA(A) receptor that act by allosterically enhancing channel activation elicited by GABA. Steroids interact with the membrane-spanning domains of the α subunits of the receptor, whereas GABA binds to pockets in the inter...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The American Society for Pharmacology and Experimental Therapeutics
2011
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3127533/ https://ncbi.nlm.nih.gov/pubmed/21498656 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.071662 |
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