Occupation of Either Site for the Neurosteroid Allopregnanolone Potentiates the Opening of the GABA(A) Receptor Induced from Either Transmitter Binding Site

Potentiating neuroactive steroids are potent and efficacious modulators of the GABA(A) receptor that act by allosterically enhancing channel activation elicited by GABA. Steroids interact with the membrane-spanning domains of the α subunits of the receptor, whereas GABA binds to pockets in the inter...

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Detalhes bibliográficos
Main Authors: Bracamontes, John, McCollum, Megan, Esch, Caroline, Li, Ping, Ann, Jason, Steinbach, Joe Henry, Akk, Gustav
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2011
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127533/
https://ncbi.nlm.nih.gov/pubmed/21498656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.071662
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