Occupation of Either Site for the Neurosteroid Allopregnanolone Potentiates the Opening of the GABA(A) Receptor Induced from Either Transmitter Binding Site

Potentiating neuroactive steroids are potent and efficacious modulators of the GABA(A) receptor that act by allosterically enhancing channel activation elicited by GABA. Steroids interact with the membrane-spanning domains of the α subunits of the receptor, whereas GABA binds to pockets in the inter...

Full description

Saved in:
Bibliographic Details
Main Authors: Bracamontes, John, McCollum, Megan, Esch, Caroline, Li, Ping, Ann, Jason, Steinbach, Joe Henry, Akk, Gustav
Format: Artigo
Language:Inglês
Published: The American Society for Pharmacology and Experimental Therapeutics 2011
Subjects:
Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127533/
https://ncbi.nlm.nih.gov/pubmed/21498656
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.111.071662
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items