p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

Suppression of macroautophagy, due to mutations or through processes linked to aging, results in the accumulation of cytoplasmic substrates that are normally eliminated by the pathway. This is a significant problem in long-lived cells like neurons, where pathway defects can result in the accumulatio...

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Bibliografiske detaljer
Main Authors: Bartlett, Bryan J, Isakson, Pauline, Lewerenz, Jan, Sanchez, Heriberto, Kotzebue, Roxanne W, Cumming, Robert, Harris, Greg L, Nezis, Ioannis P, Schubert, David, Simonsen, Anne, Finley, Kim D
Format: Artigo
Sprog:Inglês
Udgivet: Landes Bioscience 2011
Fag:
Basic Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127048/
https://ncbi.nlm.nih.gov/pubmed/21325881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.6.14943
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