p62, Ref(2)P and ubiquitinated proteins are conserved markers of neuronal aging, aggregate formation and progressive autophagic defects

Suppression of macroautophagy, due to mutations or through processes linked to aging, results in the accumulation of cytoplasmic substrates that are normally eliminated by the pathway. This is a significant problem in long-lived cells like neurons, where pathway defects can result in the accumulatio...

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Bibliographische Detailangaben
Hauptverfasser: Bartlett, Bryan J, Isakson, Pauline, Lewerenz, Jan, Sanchez, Heriberto, Kotzebue, Roxanne W, Cumming, Robert, Harris, Greg L, Nezis, Ioannis P, Schubert, David, Simonsen, Anne, Finley, Kim D
Format: Artigo
Sprache:Inglês
Veröffentlicht: Landes Bioscience 2011
Schlagworte:
Basic Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127048/
https://ncbi.nlm.nih.gov/pubmed/21325881
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/auto.7.6.14943
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