Ref(2)P, the Drosophila melanogaster homologue of mammalian p62, is required for the formation of protein aggregates in adult brain

p62 has been proposed to mark ubiquitinated protein bodies for autophagic degradation. We report that the Drosophila melanogaster p62 orthologue, Ref(2)P, is a regulator of protein aggregation in the adult brain. We demonstrate that Ref(2)P localizes to age-induced protein aggregates as well as to a...

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Bibliographic Details
Main Authors: Nezis, Ioannis P., Simonsen, Anne, Sagona, Antonia P., Finley, Kim, Gaumer, Sébastien, Contamine, Didier, Rusten, Tor Erik, Stenmark, Harald, Brech, Andreas
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
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Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2290837/
https://ncbi.nlm.nih.gov/pubmed/18347073
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200711108
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