The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity

SQSTM1/p62 (sequestosome 1) is a critical macroautophagy/autophagy receptor that promotes the formation and degradation of ubiquitinated aggregates. SQSTM1 can be modified by ubiquitination, and this modification modulates its autophagic activity. However, the molecular mechanisms underpinning its r...

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Bibliographische Detailangaben
Veröffentlicht in:Autophagy
Hauptverfasser: Peng, Hong, Yang, Fang, Hu, Qianwen, Sun, Jian, Peng, Cheng, Zhao, Yao, Huang, Chuanxin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2019
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7138243/
https://ncbi.nlm.nih.gov/pubmed/31241013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1635381
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