Загрузка...
The ubiquitin-specific protease USP8 directly deubiquitinates SQSTM1/p62 to suppress its autophagic activity
SQSTM1/p62 (sequestosome 1) is a critical macroautophagy/autophagy receptor that promotes the formation and degradation of ubiquitinated aggregates. SQSTM1 can be modified by ubiquitination, and this modification modulates its autophagic activity. However, the molecular mechanisms underpinning its r...
Сохранить в:
| Опубликовано в: : | Autophagy |
|---|---|
| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Taylor & Francis
2019
|
| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7138243/ https://ncbi.nlm.nih.gov/pubmed/31241013 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15548627.2019.1635381 |
| Метки: |
Добавить метку
Нет меток, Требуется 1-ая метка записи!
|