Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells

BACKGROUND: Treatment with anti-estrogens or aromatase inhibitors is commonly used for patients with estrogen receptor-positive (ER(+)) breast cancers; however resistant disease develops almost inevitably, requiring a choice of secondary therapy. One possibility is to use inhibitors of the PI3K/mTOR...

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Hlavní autoři: Leung, Euphemia, Kim, Ji Eun, Rewcastle, Gordon W, Finlay, Graeme J, Baguley, Bruce C
Médium: Artigo
Jazyk:Inglês
Vydáno: Landes Bioscience 2011
Témata:
Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3127046/
https://ncbi.nlm.nih.gov/pubmed/21464613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/cbt.11.11.15527
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