Comparison of the effects of the PI3K/mTOR inhibitors NVP-BEZ235 and GSK2126458 on tamoxifen-resistant breast cancer cells

Por Leung, Euphemia, Kim, Ji Eun, Rewcastle, Gordon W, Finlay, Graeme J, Baguley, Bruce C
Publicado em 2011

Potentiation of Growth Inhibitory Responses of the mTOR Inhibitor Everolimus by Dual mTORC1/2 Inhibitors in Cultured Breast Cancer Cell Lines

Por Leung, Euphemia Y., Askarian-Amiri, Marjan, Finlay, Graeme J., Rewcastle, Gordon W., Baguley, Bruce C.
Publicado no PLoS One (2015)

Identification of cyclohexanone derivatives that act as catalytic inhibitors of topoisomerase I: effects on tamoxifen-resistant MCF-7 cancer cells

Por Leung, Euphemia, Rewcastle, Gordon W., Joseph, Wayne R., Rosengren, Rhonda J., Larsen, Lesley, Baguley, Bruce C.
Publicado em 2011

Effects of acutely inhibiting PI3K isoforms and mTOR on regulation of glucose metabolism in vivo

Por Smith, Greg C., Ong, Wee Kiat, Rewcastle, Gordon W., Kendall, Jackie D., Han, Weiping, Shepherd, Peter R.
Publicado em 2012

Relationships between Signaling Pathway Usage and Sensitivity to a Pathway Inhibitor: Examination of Trametinib Responses in Cultured Breast Cancer Lines

Por Leung, Euphemia Y., Kim, Ji Eun, Askarian-Amiri, Marjan, Rewcastle, Gordon W., Finlay, Graeme J., Baguley, Bruce C.
Publicado em 2014

Inhibitors of pan-PI3K Signaling Synergize with BRAF or MEK Inhibitors to Prevent BRAF-Mutant Melanoma Cell Growth

Por Sweetlove, Melanie, Wrightson, Emma, Kolekar, Sharada, Rewcastle, Gordon W., Baguley, Bruce C., Shepherd, Peter R., Jamieson, Stephen M. F.
Publicado no Front Oncol (2015)

Evidence for functional redundancy of class IA PI3K isoforms in insulin signalling

Por Chaussade, Claire, Rewcastle, Gordon W., Kendall, Jackie D., Denny, William A., Cho, Kitty, Grønning, Line M., Chong, Mei Ling, Anagnostou, Sasha H., Jackson, Shaun P., Daniele, Nathalie, Shepherd, Peter R.
Publicado em 2007

A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types

Por Jamieson, Stephen, Flanagan, Jack U., Kolekar, Sharada, Buchanan, Christina, Kendall, Jackie D., Lee, Woo-Jeong, Rewcastle, Gordon W., Denny, William A., Singh, Ripudaman, Dickson, James, Baguley, Bruce C., Shepherd, Peter R.
Publicado em 2011

Biological characterization of SN32976, a selective inhibitor of PI3K and mTOR with preferential activity to PI3Kα, in comparison to established pan PI3K inhibitors

Por Rewcastle, Gordon W, Kolekar, Sharada, Buchanan, Christina M, Gamage, Swarna A, Giddens, Anna C, Tsang, Kit Y, Kendall, Jackie D, Singh, Ripudaman, Lee, Woo-Jeong, Smith, Greg C, Han, Weiping, Matthews, David J, Denny, William A, Shepherd, Peter R, Jamieson, Stephen M.F
Publicado no Oncotarget (2017)