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A novel role for c-Jun N-terminal kinase and phosphoinositide 3-kinase in the liver X receptor-mediated induction of macrophage gene expression

Liver X receptors (LXRs) are ligand-dependent transcription factors that are activated by metabolites of cholesterol, oxysterols, and a number of synthetic agonists. LXRs play potent anti-atherogenic roles in part by stimulating the efflux of cholesterol from macrophage foam cells. The LXR-induced e...

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Détails bibliographiques
Auteurs principaux: Huwait, Etimad A., Greenow, Kirsty R., Singh, Nishi N., Ramji, Dipak P.
Format: Artigo
Langue:Inglês
Publié: Elsevier Science Ltd 2011
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126994/
https://ncbi.nlm.nih.gov/pubmed/21070853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.11.002
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