Selective GABA Transporter Inhibitors Tiagabine and EF1502 Exhibit Mechanistic Differences in Their Ability to Modulate the Ataxia and Anticonvulsant Action of the Extrasynaptic GABA(A) Receptor Agonist Gaboxadol

Modulation of the extracellular levels of GABA via inhibition of the synaptic GABA transporter GAT1 by the clinically effective and selective GAT1 inhibitor tiagabine [(R)-N-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid; Gabitril] has proven to be an effective treatment strategy for focal se...

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Main Authors: Madsen, Karsten K., Ebert, Bjarke, Clausen, Rasmus P., Krogsgaard-Larsen, Povl, Schousboe, Arne, White, H. Steve
格式: Artigo
語言:Inglês
出版: The American Society for Pharmacology and Experimental Therapeutics 2011
主題:
Neuropharmacology
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126646/
https://ncbi.nlm.nih.gov/pubmed/21450931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.111.179671
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