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Molecular basis for the high THIP/gaboxadol sensitivity of extrasynaptic GABA(A) receptors

Extrasynaptic GABA(A) receptors (eGABARs) allow ambient GABA to tonically regulate neuronal excitability and are implicated as targets for ethanol and anesthetics. These receptors are thought to be heteropentameric proteins made up of two α subunits—either α4 or α6—two β2 or β3 subunits, and one δ s...

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Detalhes bibliográficos
Main Authors: Meera, Pratap, Wallner, Martin, Otis, Thomas S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3191842/
https://ncbi.nlm.nih.gov/pubmed/21795619
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/jn.00450.2011
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