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Etomidate, propofol and the neurosteroid THDOC increase the GABA efficacy of recombinant α4β3δ and α4β3 GABA(A) receptors expressed in HEK cells

General anesthetics, once thought to exert their effects through non-specific membrane effects, have highly specific ion channel targets that can silence neuronal populations in the nervous system, thereby causing unconsciousness and immobility, characteristic of general anesthesia. Inhibitory GABA(...

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Main Authors: Meera, Pratap, Olsen, Richard W., Otis, Thomas S., Wallner, Martin
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2659766/
https://ncbi.nlm.nih.gov/pubmed/18778723
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2008.08.011
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