Ethanol potently and competitively inhibits binding of the alcohol antagonist Ro15-4513 to α(4/6)β(3)δ GABA(A) receptors

Although GABA(A) receptors have long been implicated in mediating ethanol (EtOH) actions, receptors containing the “nonsynaptic” δ subunit only recently have been shown to be uniquely sensitive to EtOH. Here, we show that δ subunit-containing receptors bind the imidazo-benzodiazepines (BZs) flumazen...

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Detalhes bibliográficos
Main Authors: Hanchar, H. Jacob, Chutsrinopkun, Panida, Meera, Pratap, Supavilai, Porntip, Sieghart, Werner, Wallner, Martin, Olsen, Richard W.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2006
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1482528/
https://ncbi.nlm.nih.gov/pubmed/16581914
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0509903103
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