Topoisomerase IV, alone, unknots DNA in E. coli

Knotted DNA has potentially devastating effects on cells. By using two site-specific recombination systems, we tied all biologically significant simple DNA knots in Escherichia coli. When topoisomerase IV activity was blocked, either with a drug or in a temperature-sensitive mutant, the knotted reco...

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Bibliografske podrobnosti
Main Authors: Deibler, Richard W., Rahmati, Sonia, Zechiedrich, E. Lynn
Format: Artigo
Jezik:Inglês
Izdano: Cold Spring Harbor Laboratory Press 2001
Teme:
Research Paper
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC312656/
https://ncbi.nlm.nih.gov/pubmed/11274059
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.872301
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