Natural Substrate Concentrations Can Modulate the Prophylactic Efficacy of Nucleotide HIV Reverse Transcriptase Inhibitors

Preexposure prophylaxis (PrEP) with antiretroviral drugs is a novel human immunodeficiency virus (HIV) prevention strategy. It is generally thought that high systemic and mucosal drug levels are sufficient for protection. We investigated whether GS7340, a next-generation tenofovir (TFV) prodrug that...

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Detalhes bibliográficos
Main Authors: García-Lerma, J. Gerardo, Aung, Wutyi, Cong, Mian-er, Zheng, Qi, Youngpairoj, Ae S., Mitchell, James, Holder, Angela, Martin, Amy, Kuklenyik, Susan, Luo, Wei, Lin, Carol Yen-Chin, Hanson, Debra L., Kersh, Ellen, Pau, Chou-Pong, Ray, Adrian S., Rooney, James F., Lee, William A., Heneine, Walid
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126530/
https://ncbi.nlm.nih.gov/pubmed/21525346
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00311-11
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