Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum

Mycophenolic acid (MPA) is the active ingredient in the increasingly important immunosuppressive pharmaceuticals CellCept (Roche) and Myfortic (Novartis). Despite the long history of MPA, the molecular basis for its biosynthesis has remained enigmatic. Here we report the discovery of a polyketide sy...

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Détails bibliographiques
Auteurs principaux: Regueira, Torsten Bak, Kildegaard, Kanchana Rueksomtawin, Hansen, Bjarne Gram, Mortensen, Uffe H., Hertweck, Christian, Nielsen, Jens
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2011
Sujets:
Biotechnology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126426/
https://ncbi.nlm.nih.gov/pubmed/21398490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03015-10
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