Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum

Mycophenolic acid (MPA) is the active ingredient in the increasingly important immunosuppressive pharmaceuticals CellCept (Roche) and Myfortic (Novartis). Despite the long history of MPA, the molecular basis for its biosynthesis has remained enigmatic. Here we report the discovery of a polyketide sy...

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Hlavní autoři: Regueira, Torsten Bak, Kildegaard, Kanchana Rueksomtawin, Hansen, Bjarne Gram, Mortensen, Uffe H., Hertweck, Christian, Nielsen, Jens
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2011
Témata:
Biotechnology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126426/
https://ncbi.nlm.nih.gov/pubmed/21398490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03015-10
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