Molecular Basis for Mycophenolic Acid Biosynthesis in Penicillium brevicompactum

Mycophenolic acid (MPA) is the active ingredient in the increasingly important immunosuppressive pharmaceuticals CellCept (Roche) and Myfortic (Novartis). Despite the long history of MPA, the molecular basis for its biosynthesis has remained enigmatic. Here we report the discovery of a polyketide sy...

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Main Authors: Regueira, Torsten Bak, Kildegaard, Kanchana Rueksomtawin, Hansen, Bjarne Gram, Mortensen, Uffe H., Hertweck, Christian, Nielsen, Jens
Formáid: Artigo
Teanga:Inglês
Foilsithe: American Society for Microbiology 2011
Ábhair:
Biotechnology
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126426/
https://ncbi.nlm.nih.gov/pubmed/21398490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.03015-10
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