Involvement of a Natural Fusion of a Cytochrome P450 and a Hydrolase in Mycophenolic Acid Biosynthesis

Mycophenolic acid (MPA) is a fungal secondary metabolite and the active component in several immunosuppressive pharmaceuticals. The gene cluster coding for the MPA biosynthetic pathway has recently been discovered in Penicillium brevicompactum, demonstrating that the first step is catalyzed by MpaC,...

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Bibliographic Details
Main Authors: Hansen, Bjarne Gram, Mnich, Ewelina, Nielsen, Kristian Fog, Nielsen, Jakob Blæsbjerg, Nielsen, Morten Thrane, Mortensen, Uffe Hasbro, Larsen, Thomas Ostenfeld, Patil, Kiran Raosaheb
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Biotechnology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416377/
https://ncbi.nlm.nih.gov/pubmed/22544261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.07955-11
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