Involvement of a Natural Fusion of a Cytochrome P450 and a Hydrolase in Mycophenolic Acid Biosynthesis

Mycophenolic acid (MPA) is a fungal secondary metabolite and the active component in several immunosuppressive pharmaceuticals. The gene cluster coding for the MPA biosynthetic pathway has recently been discovered in Penicillium brevicompactum, demonstrating that the first step is catalyzed by MpaC,...

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Detalhes bibliográficos
Main Authors: Hansen, Bjarne Gram, Mnich, Ewelina, Nielsen, Kristian Fog, Nielsen, Jakob Blæsbjerg, Nielsen, Morten Thrane, Mortensen, Uffe Hasbro, Larsen, Thomas Ostenfeld, Patil, Kiran Raosaheb
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416377/
https://ncbi.nlm.nih.gov/pubmed/22544261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.07955-11
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