Involvement of a Natural Fusion of a Cytochrome P450 and a Hydrolase in Mycophenolic Acid Biosynthesis

Mycophenolic acid (MPA) is a fungal secondary metabolite and the active component in several immunosuppressive pharmaceuticals. The gene cluster coding for the MPA biosynthetic pathway has recently been discovered in Penicillium brevicompactum, demonstrating that the first step is catalyzed by MpaC,...

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Bibliographische Detailangaben
Hauptverfasser: Hansen, Bjarne Gram, Mnich, Ewelina, Nielsen, Kristian Fog, Nielsen, Jakob Blæsbjerg, Nielsen, Morten Thrane, Mortensen, Uffe Hasbro, Larsen, Thomas Ostenfeld, Patil, Kiran Raosaheb
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Biotechnology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416377/
https://ncbi.nlm.nih.gov/pubmed/22544261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.07955-11
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