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Involvement of a Natural Fusion of a Cytochrome P450 and a Hydrolase in Mycophenolic Acid Biosynthesis

Mycophenolic acid (MPA) is a fungal secondary metabolite and the active component in several immunosuppressive pharmaceuticals. The gene cluster coding for the MPA biosynthetic pathway has recently been discovered in Penicillium brevicompactum, demonstrating that the first step is catalyzed by MpaC,...

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Bibliografische gegevens
Hoofdauteurs: Hansen, Bjarne Gram, Mnich, Ewelina, Nielsen, Kristian Fog, Nielsen, Jakob Blæsbjerg, Nielsen, Morten Thrane, Mortensen, Uffe Hasbro, Larsen, Thomas Ostenfeld, Patil, Kiran Raosaheb
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Microbiology 2012
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3416377/
https://ncbi.nlm.nih.gov/pubmed/22544261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.07955-11
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