Inhibition of Homologous Recombination by DNA-Dependent Protein Kinase Requires Kinase Activity, Is Titratable, and Is Modulated by Autophosphorylation

How a cell chooses between nonhomologous end joining (NHEJ) and homologous recombination (HR) to repair a double-strand break (DSB) is a central and largely unanswered question. Although there is evidence of competition between HR and NHEJ, because of the DNA-dependent protein kinase (DNA-PK)'s...

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Bibliographic Details
Main Authors: Neal, Jessica A., Dang, Van, Douglas, Pauline, Wold, Marc S., Lees-Miller, Susan P., Meek, Katheryn
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126343/
https://ncbi.nlm.nih.gov/pubmed/21300785
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01298-10
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