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Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation
DNA-dependent protein kinase (DNA-PK) orchestrates DNA repair by regulating access to breaks through autophosphorylations within two clusters of sites (ABCDE and PQR). Blocking ABCDE phosphorylation (by alanine mutation) imparts a dominant negative effect, rendering cells hypersensitive to agents th...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Microbiology
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4054291/ https://ncbi.nlm.nih.gov/pubmed/24687855 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01554-13 |
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