Unraveling the Complexities of DNA-Dependent Protein Kinase Autophosphorylation

DNA-dependent protein kinase (DNA-PK) orchestrates DNA repair by regulating access to breaks through autophosphorylations within two clusters of sites (ABCDE and PQR). Blocking ABCDE phosphorylation (by alanine mutation) imparts a dominant negative effect, rendering cells hypersensitive to agents th...

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Main Authors: Neal, Jessica A., Sugiman-Marangos, Seiji, VanderVere-Carozza, Pamela, Wagner, Mike, Turchi, John, Lees-Miller, Susan P., Junop, Murray S., Meek, Katheryn
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2014
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4054291/
https://ncbi.nlm.nih.gov/pubmed/24687855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01554-13
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