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N-Terminal Hemagglutinin Tag Renders Lysine-Deficient APOBEC3G Resistant to HIV-1 Vif-Induced Degradation by Reduced Polyubiquitination

APOBEC3G, a potent HIV-1 host restriction factor, is overcome by HIV-1 viral infectivity factor (Vif), which induces its polyubiquitination and proteasomal degradation. Here we show that lysine-deficient APOBEC3G with an N-terminal hemagglutinin (HA) tag fusion (HA-A3G20K/R) was resistant to HIV-1 V...

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書誌詳細
主要な著者: Wang, Yudi, Shao, Qiujia, Yu, Xianghui, Kong, Wei, Hildreth, James E. K., Liu, Bindong
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126286/
https://ncbi.nlm.nih.gov/pubmed/21345952
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01925-10
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