HIV-1 Vif inhibits G to A hypermutations catalyzed by virus-encapsidated APOBEC3G to maintain HIV-1 infectivity

BACKGROUND: HIV-1 viral infectivity factor (Vif) is an essential accessory protein for HIV-1 replication. The predominant function of Vif is to counteract Apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G, A3G), a potent host restriction factor that inhibits HIV-1 replicat...

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Detalhes bibliográficos
Main Authors: Wang, Yudi, Kinlock, Ballington L, Shao, Qiujia, Turner, Tiffany M, Liu, Bindong
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200127/
https://ncbi.nlm.nih.gov/pubmed/25304135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12977-014-0089-5
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