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HIV-1 Vif-mediated ubiquitination/degradation of APOBEC3G involves four critical lysine residues in its C-terminal domain

During coevolution with the host, HIV-1 developed the ability to hijack the cellular ubiquitin/proteasome degradation pathway to counteract the antiviral activity of APOBEC3G (A3G), a host cytidine deaminase that can block HIV-1 replication. Abrogation of A3G function involves the HIV-1 Vif protein,...

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Detalhes bibliográficos
Main Authors: Iwatani, Yasumasa, Chan, Denise S. B., Liu, Lin, Yoshii, Hiroaki, Shibata, Junko, Yamamoto, Naoki, Levin, Judith G., Gronenborn, Angela M., Sugiura, Wataru
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2772817/
https://ncbi.nlm.nih.gov/pubmed/19887642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906652106
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