Biochemical Activities of Highly Purified, Catalytically Active Human APOBEC3G: Correlation with Antiviral Effect

APOBEC3G (APO3G), a cytidine deaminase with two zinc finger domains, inhibits human immunodeficiency virus type 1 replication in the absence of Vif. Here, we provide a comprehensive molecular analysis of the deaminase and nucleic acid binding activities of human APO3G using a pure system containing...

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Detalhes bibliográficos
Main Authors: Iwatani, Yasumasa, Takeuchi, Hiroaki, Strebel, Klaus, Levin, Judith G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2006
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1472592/
https://ncbi.nlm.nih.gov/pubmed/16731938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02680-05
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