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The Early Interferon Response to Rotavirus Is Regulated by PKR and Depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3

In mouse embryonic fibroblasts (MEFs), the bovine rotavirus (UK strain) but not the simian rhesus rotavirus (RRV) robustly triggers beta interferon (IFN-β) secretion, resulting in an IFN-dependent restriction of replication. We now find that both rotavirus strains trigger antiviral transcriptional r...

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Main Authors: Sen, Adrish, Pruijssers, Andrea J., Dermody, Terence S., García-Sastre, Adolfo, Greenberg, Harry B.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3126121/
https://ncbi.nlm.nih.gov/pubmed/21307186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02634-10
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