IRF3 Inhibition by Rotavirus NSP1 Is Host Cell and Virus Strain Dependent but Independent of NSP1 Proteasomal Degradation

Rotavirus host range restriction forms a basis for strain attenuation although the underlying mechanisms are unclear. In mouse fibroblasts, the inability of rotavirus NSP1 to mediate interferon (IFN) regulatory factor 3 (IRF3) degradation correlates with IFN-dependent restricted replication of the b...

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Hlavní autoři: Sen, Adrish, Feng, Ningguo, Ettayebi, Khalil, Hardy, Michele E., Greenberg, Harry B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology (ASM) 2009
Témata:
Cellular Response to Infection
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753142/
https://ncbi.nlm.nih.gov/pubmed/19656876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01186-09
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