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Impaired ovarian development and reduced fertility in female mice deficient in Skp2
p27 is a major negative regulator of somatic cellular proliferation, and its down-regulation has been shown to be associated with cancer development. Targeted disruption ofp27 results in complete loss of fertility in female mice, suggesting that it plays a significant role in the development of fema...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Blackwell Science Inc
2011
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3125901/ https://ncbi.nlm.nih.gov/pubmed/21450015 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1469-7580.2011.01370.x |
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