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Obox1 deficiency impairs fertility in female mice

OBOX1 is a maternal factor involved in oogenesis and follicle development, yet its specific role remains unclear. Here, we demonstrated that Obox1 knockout female mice exhibit subfertility, characterized by reduced litter size and impaired ovulation. These oocytes show minimal disruption in early em...

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Principais autores: Li Wu, Jiacheng Shen, Zhenzhen Hou, Yinli Zhang, Yan Bi, Ran Zhang, Heping Bai, Wen Ye, Kang Chen, Jiang Zhu, Chenxiang Xi, Yiliang Xu, Xiaochen Kou, Yanhong Zhao, Chong Li, Hengyu Fan, Rongrong Le, Yixuan Wang, Xiaocui Xu, Shaohua Xu, Hong Wang, Shaorong Gao, Lan Kang
Formato: Artigo
Idioma:Inglês
Publicado em: KeAi Communications Co. Ltd. 2025-07-01
coleção:Fundamental Research
Assuntos:
Subfertility
Hormone deficiency
Abnormal luteinization
Aberrant steroidogenesis
Oocyte-granulosa cell interactions
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2667325825002055
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