Detection of newly synthesized RNA reveals transcriptional reprogramming during ZGA and a role of Obox3 in totipotency acquisition

Summary: Zygotic genome activation (ZGA) after fertilization enables the maternal-to-zygotic transition. However, the global view of ZGA, particularly at initiation, is incompletely understood. Here, we develop a method to capture and sequence newly synthesized RNA in early mouse embryos, providing...

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Bibliografische gegevens

Hoofdauteurs:	Mizuki Sakamoto, Aoi Ito, Sayaka Wakayama, Hiroyuki Sasaki, Teruhiko Wakayama, Takashi Ishiuchi
Formaat:	Artigo
Taal:	Inglês
Gepubliceerd in:	Elsevier 2024-04-01
Reeks:	Cell Reports
Onderwerpen:	CP: Developmental biology CP: Molecular biology
Online toegang:	http://www.sciencedirect.com/science/article/pii/S2211124724004467
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