Lentivirally mediated GSK-3β silencing in the hippocampal dentate gyrus induces antidepressant-like effects in stressed mice

Inhibition of glycogen synthase kinase-3 (GSK-3) by pharmacological tools can produce antidepressant-like effects in rodents. However, the GSK-3 isoform(s) and brain region(s) involved in regulating these behavioral effects remain elusive. We studied the effects of bilateral intra-hippocampal inject...

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Detalhes bibliográficos
Main Authors: Omata, Naoto, Chiu, Chi-Tso, Moya, Pablo R., Leng, Yan, Wang, Zhifei, Hunsberger, Joshua G., Leeds, Peter, Chuang, De-Maw
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125712/
https://ncbi.nlm.nih.gov/pubmed/20604988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1017/S1461145710000726
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