Lentiviral silencing of GSK-3β in adult dentate gyrus impairs contextual fear memory and synaptic plasticity

Attempts have been made to use glycogen synthase kinase-3 beta (GSK3β) inhibitors for prophylactic treatment of neurocognitive conditions. However the use of lithium, a non-specific inhibitor of GSK3β results in mild cognitive impairment in humans. The effects of global GSK3β inhibition or knockout...

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Bibliographische Detailangaben
Veröffentlicht in:Front Behav Neurosci
Hauptverfasser: Chew, Benjamin, Ryu, Jae Ryun, Ng, Teclise, Ma, Dongliang, Dasgupta, Ananya, Neo, Sin Hui, Zhao, Jing, Zhong, Zhong, Bichler, Zoë, Sajikumar, Sreedharan, Goh, Eyleen L. K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2015
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4477161/
https://ncbi.nlm.nih.gov/pubmed/26157370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2015.00158
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