Gain of function of cardiac ryanodine receptor in a rat model of type 1 diabetes

AIMS: Ventricular myocytes isolated from hearts of streptozotocin (STZ)-diabetic rats exhibit increased spontaneous Ca(2+) release. Studies attribute this defect to an enhancement in activity of type 2 ryanodine receptor (RyR2). To date, underlying reasons for RyR2 dysregulation remain undefined. Th...

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Hlavní autoři: Tian, Chengju, Hong Shao, Chun, Moore, Caronda J., Kutty, Shelby, Walseth, Timothy, DeSouza, Cyrus, Bidasee, Keshore R.
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2011
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3125072/
https://ncbi.nlm.nih.gov/pubmed/21421556
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr076
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