Benzothiophene Selective Estrogen Receptor Modulators Provide Neuroprotection by a Novel GPR30-Dependent Mechanism

[Image: see text] The clinical benzothiophene SERM (BT-SERM) raloxifene was compared with estrogens in protection of primary rat neurons against oxygen-glucose deprivation (OGD). Structure−activity relationships for neuroprotection were determined for a family of BT-SERMs displaying a spectrum of ER...

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Hauptverfasser: Abdelhamid, Ramy, Luo, Jia, VandeVrede, Lawren, Kundu, Indraneel, Michalsen, Bradley, Litosh, Vladislav A., Schiefer, Isaac T., Gherezghiher, Teshome, Yao, Ping, Qin, Zhihui, Thatcher, Gregory R. J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2011
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3124785/
https://ncbi.nlm.nih.gov/pubmed/21731800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn100106a
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